2'-substituted oligomeric compounds and compositions for use in gene modulations
摘要
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a 5 portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2' substituent group on a sugar moiety that is not H or OH. 10 Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
申请公布号
AU2010201712(B2)
申请公布日期
2012.05.31
申请号
AU20100201712
申请日期
2010.04.29
申请人
ISIS PHARMACEUTICALS, INC.
发明人
CROOKE, STANELY T.;BAKER, BRENDA;ELDRUP, ANNE B.;MANOHARAN, MUTHIAH;BHAT, BALKRISHEN;GRIFFEY, RICHARD;SWAYZE, ERIC E.;PRAKASH, THAZHA P.