| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an agent effective for various refractory skin diseases, specifically atopic dermatitis skin. <P>SOLUTION: An external use composition for skin includes: a tarajo holly leaf extract and a Japanese knotweed leaf extract; a brown algae extract; and an egg shell membrane derived peptide (ESM-P) having a molecular mass of 3 kDa or higher. Preferably, the composition is used to treat a disease or condition of skin relating to a filaggrin metabolism anomaly, and has an effect of eliminating itches and pains based on inhibition of histamine release and cyclooxygenase (COX)-2 activity, an effect of regulating excessive immune response based on inhibition of cytokine generation, and an effect of normalizing epidermis formation based on acceleration of filaggrin synthesis. <P>COPYRIGHT: (C)2012,JPO&INPIT |
