SYSTEM AND METHOD FOR AUTOMATED GENERATION AND HANDLING OF LIQUID MIXTURES

摘要

The invention relates to a system (1) comprising a microfluidic subsystem and a supplying part for supplying said microfluidic subsystem with liquids, said supplying part comprising
a first valve (14, 29, 46) and a first fluidic duct (10, 25, 28), for connecting said first valve (14, 29, 46) with said microfluidic subsystem and supplying a first liquid, and
a second valve (15) and a second fluidic duct (11), for connecting said second valve (15) with said microfluidic subsystem and supplying a second liquid, characterized in that
said first valve (14, 29, 46) and said second valve (15) are suitable for closing with time resolution not worse than 100msec,
and
for each of said first fluidic duct, second fluidic duct, first valve and second valve the following condition is fulfilled:
the hydraulic resistance R out of the fluidic duct is at least 10 times higher, preferably 100 times higher, than the hydraulic resistance R in of the inlet of the valve
and
a) the fluidic duct is made of material, whose Young modulus E is not lower than 0.002GPa, preferably of silicone rubber, Teflon, polyethylene, PEEK, glass or steel, while the length L of said fluidic duct and the surface area A of the lumen of the said fluidic duct are so adjusted that L 2 /A is lower than 8—�10 6 , preferably lower than 8—�10 5 or
b) the fluidic duct is made of material, whose Young modulus E is not lower than 2GPa, preferably of polyethylene, PEEK, glass or steel, while the length L of said fluidic duct and the surface area A of the lumen of the said fluidic duct are so adjusted that L 2 /A is lower than 4—�10 9 , preferably lower than 4—�10 8 or
c) the fluidic duct is made of material, whose Young modulus E is not lower than 50GPa, preferably of glass or steel, while the length L of said fluidic duct and the surface area A of the lumen of the said fluidic duct are so adjusted that L 2 /A is lower than 8—�10 9 , preferably lower than 8—�10 8 .