发明名称 |
COMPOSITIONS AND METHODS FOR PREPARING STAPHYLOCOCCUS AUREUS SEROTYPE 5 AND 8 CAPSULAR POLYSACCHARIDE CONJUGATE IMMUNOGENIC COMPOSITIONS |
摘要 |
<p>The present invention relates to immunogenic conjugates comprising S. auerus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).</p> |
申请公布号 |
KR20120048568(A) |
申请公布日期 |
2012.05.15 |
申请号 |
KR20127001730 |
申请日期 |
2010.06.22 |
申请人 |
WYETH LLC |
发明人 |
FREESE STEPHEN JOHN;ANDERSON ANNALIESA;PAVLIAK VILIAM;JANSEN KATHRIN UTE;DODGE INGRID LEA;SCOTT TRACY DEE;NANRA JASDEEP SINGH;PRASAD A. KRISHNA;GREEN BRUCE ARTHUR |
分类号 |
A61K39/085;A61K47/48;A61P37/00 |
主分类号 |
A61K39/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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