HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

摘要

Disclosed is a compound of formula (I) where the substituents are as disclosed in the specification and examples of compounds of formula (I) are (S)-4-(3-( 6,7-dichloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide and (S)-4-(2-oxo-3-(7-( trifluoromethyl)-3,4-dihydroisoquinolin-2(1H)yl)pyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating conditions such as arthritis, migraines, pain and epilepsy.