METHODS FOR IDENTIFYING INHIBITORS OF ABETA42 OLIGOMERS

摘要

The invention herein is directed to immunoassays for the detection of ?ß42 oligomers. The inventive assays are based on the observations herein that the presence of ?ß42 oligomers in a preparation is directly related to a decrease in a C-terminal (CT) immunosignal and a correlated increase in an N-terminal (NT) immunosignal, relative to the immunosignal generated in the absence of ?ß42 oligomers, in an ?ß42 CT and NT ELISA assay and an ?ß42 CT AlphaLISA assay. The invention herein involves the use of these assays alone or in combination to screen for inhibitors of ?ß42 oligomerization.