发明名称 |
Method of Storing a Vaccine Containing an Aluminum Adjuvant |
摘要 |
The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon™; and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.
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申请公布号 |
US2012091026(A1) |
申请公布日期 |
2012.04.19 |
申请号 |
US201113274714 |
申请日期 |
2011.10.17 |
申请人 |
CHACORNAC ISABELLE;IKHELEF-GRIBI NABILA;RONZON FREDERIC;TIREFORT JULIEN;LENTSCH GRAF SANDRINE;SANOFI PASTEUR |
发明人 |
CHACORNAC ISABELLE;IKHELEF-GRIBI NABILA;RONZON FREDERIC;TIREFORT JULIEN;LENTSCH GRAF SANDRINE |
分类号 |
B65D85/00;B65B7/28 |
主分类号 |
B65D85/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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