发明名称 |
TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRS2 AND TRANSCRIPTION FACTOR E3 (TFE3) |
摘要 |
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Insulin Receptor Substrate 2 (IRS2) polynucleotides, in particular, by targeting natural antisense polynucleotides of Insulin Receptor Substrate 2 (IRS2) polynucleotides and Transcription factor E3 (TFE3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRS2. |
申请公布号 |
WO2011082281(A3) |
申请公布日期 |
2012.04.12 |
申请号 |
WO2010US62463 |
申请日期 |
2010.12.30 |
申请人 |
OPKO CURNA, LLC;COLLARD, JOSEPH;KHORKOVA SHERMAN, OLGA |
发明人 |
COLLARD, JOSEPH;KHORKOVA SHERMAN, OLGA |
分类号 |
C12N15/113;A61K31/7088;A61K48/00;C12N15/63 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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