发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITION OF MMP:MMP-SUBSTRATE INTERACTIONS |
摘要 |
The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGFβ). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.
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申请公布号 |
US2012088722(A1) |
申请公布日期 |
2012.04.12 |
申请号 |
US201113269518 |
申请日期 |
2011.10.07 |
申请人 |
D'ANGELO MARINA;SELIM ABDULHAFEZ |
发明人 |
D'ANGELO MARINA;SELIM ABDULHAFEZ |
分类号 |
A61K38/02;A61K38/57;A61P19/04;A61P19/08;C07K2/00;C07K7/06;C07K7/08;C07K14/47;C07K16/18;C07K19/00;C12N9/99 |
主分类号 |
A61K38/02 |
代理机构 |
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主权项 |
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地址 |
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