METHOD OF TREATING LOCALLY ADVANCED ONCOLOGICAL DISEASES IN EXPERIMENT

摘要

FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, oncology, and may be used for treating locally advanced oncological diseases in experiment. For this purpose, a malignant growth is exposed to infrared laser light in molecular oxygen absorption band. The exposure is performed in a pulse mode at power density specified to avoid thermal tissue coagulation and to provide generation of chemically active electron-excited oxygen in tissue. The exposure is preceded by introducing the photosensitiser tetrahydroporphyrin-tetra-n-toluene sulphonate at 5-15 mg/kg of animal model's body weight. Then in 0.5-2 hours, a parental tumour is exposed to interstitial laser. And 8-12 hours, the metastases are covered in the range of wave harmonics 690-762 nm or 1270 nm in a single dose at power density 200-300 J/cm2. ^ EFFECT: method provides higher clinical effectiveness by increasing a penetration depth of the water-soluble photosensitiser tetrahydroporphyrin-tetra-n-toluene sulphonate introduced immediately in the tumour tissue, tumour tissue regression ensured by a apoptosis reaction; enabled use of the method in veterinary science. ^ 14 dwg