发明名称 |
METHODS FOR PREPARING NANOFORMULATIONS AND SYSTEMS FOR NANO - DELIVERY USING FOCUSED ACOUSTICS |
摘要 |
Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents. A formulation may also include a suspension of micron or submicron sized particles dispersed within a solvent. Or, a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent (e.g., liposome/micelle containing a pharmaceutical, polynucleotide, etc.). In some cases, the polydispersity index of the particle size distribution in a formulation is less than 0.1. Formulations may be suitably prepared using focused acoustic energy that results in a reduction of the average particle size of a mixture. Alternatively, suitable formulations may be prepared using focused acoustics in a manner that does not reduce the average particle size of the mixture. |
申请公布号 |
WO2012003003(A3) |
申请公布日期 |
2012.04.05 |
申请号 |
WO2011US01171 |
申请日期 |
2011.07.01 |
申请人 |
COVARIS, INC.;BECKETT, CARL;LAUGHARN, JAMES, A, JR.;KAKUMANU, SRIKANTH |
发明人 |
BECKETT, CARL;LAUGHARN, JAMES, A, JR.;KAKUMANU, SRIKANTH |
分类号 |
B01F11/02;B01J2/18;B01J19/10 |
主分类号 |
B01F11/02 |
代理机构 |
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代理人 |
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主权项 |
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