发明名称 |
AZAINDOLIZINES AND METHODS OF USE |
摘要 |
The disclosure relates to azaindolizines of formula (I-a) with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The disclosure also relates to compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The disclosure further relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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申请公布号 |
NZ586575(A) |
申请公布日期 |
2012.03.30 |
申请号 |
NZ20080586575 |
申请日期 |
2008.12.19 |
申请人 |
GENENTECH, INC. |
发明人 |
HEALD, ROBERT;HEWITT, PETER;PRICE, STEPHEN |
分类号 |
A61K31/437;A61K31/4985;A61P35/00;C07D487/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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