HUMAN-ADAPTED HA POLYPEPTIDES, VACCINES, AND INFLUENZA TREATMENT

摘要

The disclosure provides methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections. Specifically, the disclosure provides engineered hemagglutinin (HA) polypeptides that show a strong ability to discriminate between umbrella-topology and cone-topology glycans. More specifically, the engineered HA polypeptides have certain particular amino acids residues at positions corresponding to 137, 193, 226, and 228 of the HA polypeptide. The disclosure further provides methods of using the engineered HA polypeptides for treating influenza infections in human.