| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to applying a microorganism of Lactobacillus genus, characterised by ability to specific binding with bacterium of mutans Streptococci group in which specific binding is characterised by: (i) thermal stability; and/or (ii) proteolytic stability; and/or (iii) calcium dependence; and/or (iv) formation at pH within 4.5 to 8.5; and/or (v) formation with saliva added for preparing an anti-caries composition for treating or preventing caries caused by mutans Streptococci different from Streptococcus mutans. The specific binding is analysed by the following procedures: (a) cultivation of said microorganism to a steady state; (b) mixing of said microorganism and bacterium of mutans Streptococci group which is cultivated to the steady state; (c) incubation of the mixture prepared at the stage (b) in the environment allowing formation of the aggregated microorganism and bacterium of mutans Streptococci group; and (d) detection of the aggregates by the presence of the pellet. A method for preventing and treating caries caused by mutans Streptococci different from Streptococcus mutans involves introduction of the microorganism of Lactobacillus genus showing the ability to specific binding with bacterium of mutans Streptococci group in which specific binding is characterised by the properties specified above (i)-(v). ^ EFFECT: invention provides specific binding of said microorganism of Lactobacillus genus with such strains mutans Streptococci different from Streptococcus mutans which are cariogenous dental pathogens. ^ 24 cl, 3 dwg, 1 tbl, 27 ex |
