发明名称 HDAC inhibitors
摘要 This invention provides the compound having the structure wherein n is 1-10; X is C—R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO—R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl; Z is R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl; R5 is OH or SH; and R6, R12, R13, and R14 are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO—R15 wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.
申请公布号 US8143445(B2) 申请公布日期 2012.03.27
申请号 US20080286769 申请日期 2008.10.01
申请人 KOVACH JOHN S.;JOHNSON FRANCIS;LIXTE BIOTECHNOLOGY, INC. 发明人 KOVACH JOHN S.;JOHNSON FRANCIS
分类号 C07C233/65;A61K31/16 主分类号 C07C233/65
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