COMPOSITIONS FOR TREATING CANCER TREATMENT - RELATED FATIGUE
摘要
<p>An animal model has been developed based on the understanding that a central mechanism in patients with CTRF is that chemotherapy and/or radiation initiates canonical pathways leading to the development of disrupted sleep architecture, resulting in disruption of REM sleep and fatigue and cognitive dysfunction. Drugs that restore the activity patterns and levels towards normal and/or decrease the pro - inflammatory cytokines associated with the disrupted sleep, should be effective in alleviating one or more symptoms of CTRF. Pentoxifylline was demonstrated to improve activity levels in animals treated with etoposide.</p>
申请公布号
WO2012037093(A1)
申请公布日期
2012.03.22
申请号
WO2011US51354
申请日期
2011.09.13
申请人
TENERA THERAPEUTICS, LLC;SONIS, STEPHEN;FEY, EDWARD;RUBENSTEIN, EDWARD, B.