FAM161A AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS

摘要

Objective methods for diagnosing cancer or a predisposition to developing cancer, particularly lung cancer is described herein. In one embodiment, the present invention provides a diagnostic method that utilizes the expression level of FAM161A as an index of cancer. The present invention further provides methods of assessing or determining the prognosis of a patient with lung cancer. The present invention further provides methods of screening for therapeutic substances useful in the treatment of cancer, e.g. lung cancer. The invention further provides methods of inhibiting the cancer cell growth and treating and/or preventing cancer. The invention also features double stranded molecules against FAM161A or CSNK2A2 gene, as well as vector encoding them and compositions containing them. The invention further provides a FAM161A polypeptide having a dominat-negative effect.