MULTIPLEXED SUPRAMOLECULAR ASSEMBLIES FOR NON-VIRAL DELIVERY OF GENETIC MATERIAL
摘要
The invention provides a composition comprising two or more of a) genetic material; b) a condensing agent; c) a membrane destabilizing agent; d) a targeting/stabilizing agent, and optionally e) an ionic cross-linking agent. The components of the composition can self-assemble to form particles via electrostatic and/or lipophilic interactions. Methods of making and using the composition are also provided. The compositions can be used, for example, to transfer genetic material to cells in vitro or in vivo.
申请公布号
WO2012019121(A2)
申请公布日期
2012.02.09
申请号
WO2011US46791
申请日期
2011.08.05
申请人
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;CHENG, JIANJUN;GABRIELSON, NATHAN;LICHEN, YIN