发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER |
摘要 |
The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor, is also expressed in various cancers, including ovarian cancer and uterine cancer. Six SAS1R variants have been previously identified, and they are encompassed by the invention. The present invention further provides antibodies useful for targeting SAS1R expressing cells and for killing such cells. |
申请公布号 |
WO2012019184(A2) |
申请公布日期 |
2012.02.09 |
申请号 |
WO2011US46905 |
申请日期 |
2011.08.08 |
申请人 |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;HERR, JOHN C.;EUSEBIO S. PIRES |
发明人 |
HERR, JOHN C.;EUSEBIO S. PIRES |
分类号 |
G01N33/574;A61K38/17;A61K48/00;A61P35/00;C12Q1/68;G01N33/68 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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