| 摘要 |
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein: A is 0, S, NR', or CR, wherein Ris defined herein; represents either a single or a double bond;Ris selected from: H, halogen, R, OR, SR, СООR,SON(R), N(R), СОN(R,NRС(O)Ror NRC(O)NRwherein Rand each Ris defined herein; В is NRor CR, with the proviso that one of A or В is either CRor CR, wherein Ris defined herein; К is N or CR, wherein R- is defined herein; L is N or CR, wherein Rhas the same definition as R; M is N or CR, wherein Rhas the same definition as R; Yis 0 or S; Z is N(R)Ror OR, wherein Ris H or alkyi or NRRwherein Rand Rare defined herein; and Ris H, alkyi, cycloalkyi, alkenyl, Het, alkyl-aryl, alkyl-Het;or R' is wherein Rand Rand Q are as defined herein; Yis 0 or S;Ris H, (Calkyi), (C)cycloalkyl or (C)alkyl-(C)cycloalkyI, aryl, Het, (C)alkyl-aryl or (Ci.6)alkyl-Het, all of which optionally substituted with R;or Ris covalently bonded to either of Ror Rto form a 5- or 6-membered heterocycle; a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase. |
