Dendritic cell vaccines for asparaginyl- beta - hydroxylase expressing tumors

摘要

A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH- expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ