发明名称 |
Use of melanoma inhibitory activity (MIA) protein as an early indicator for therapeutic response in melanoma |
摘要 |
The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma, inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent. |
申请公布号 |
AU2007277144(B2) |
申请公布日期 |
2012.01.19 |
申请号 |
AU20070277144 |
申请日期 |
2007.07.26 |
申请人 |
NOVARTIS AG |
发明人 |
VENETSANAKOS, ELENI;TAN, NGUYEN;HEISE, CARLA;FAURE, MICHEL |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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