| 摘要 |
Disclosed herein are compositions and methods for treating pain, and addiction, said methods comprising administering: at least one Opioid or a pharmaceutically acceptable salt thereof; and at least one of a µ- receptor partial agonist or a ?-receptor antagonist, or pharmaceutically acceptable salts thereof; in amounts effective to cause or enhance a supra-additive synergistic analgesic response to pain and for a duration effective to inhibit pain in the individual in need thereof. The co-administration of an Opioid with the µ-receptor partial agonist and the ?-receptor antagonist results in decreased tolerance, decreased dependence potential, and diminishing side effects, compared to conventional opioid therapy alone. |
