| 发明名称 |
Hyaluronic acid-methotrexate conjugate |
| 摘要 |
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids. |
| 申请公布号 |
US8088916(B2) |
申请公布日期 |
2012.01.03 |
| 申请号 |
US20050591653 |
申请日期 |
2005.03.04 |
| 申请人 |
IKEYA HITOSHI;MORIKAWA TADASHI;TAKAHASHI KOICHI;TAMURA TATSUYA;OKAMACHI AKIRA;ISHIZAWA TAKENORI;SATO HARUHIKO;HIGUCHI YOSHINOBU;DENKI KAGAKU KOGYO KABUSHIKI KAISHA |
发明人 |
IKEYA HITOSHI;MORIKAWA TADASHI;TAKAHASHI KOICHI;TAMURA TATSUYA;OKAMACHI AKIRA;ISHIZAWA TAKENORI;SATO HARUHIKO;HIGUCHI YOSHINOBU |
| 分类号 |
C08B37/00;A01N43/04;A01N43/60;A61K31/519;A61K47/48;A61P19/02;C07D475/10;C07K5/00;C07K9/00;C08B37/08 |
主分类号 |
C08B37/00 |
| 代理机构 |
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