COMPOSITIONS COMPRISING RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM INHIBITORS AND LIPOIC ACID COMPOUNDS, AND THE USE THEREOF FOR THE TREATMENT OF RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM RELATED DISORDERS

摘要

Compositions are provided which can be useful in treating a renin-angiotensin aldosterone system-related disorder. These compositions include renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, as well as other therapeutic agents, and are useful in treating hypertension, stroke, metabolic syndrome, or other renin-angiotensin aldosterone system-related disorders in a subject. The compositions are also useful in improving vasodilation, reducing proteinuria, and reducing insulin resistance in a subject. Pharmaceutical compositions and methods of treatment using the compositions are further provided.