发明名称 |
EXPRESSION SYSTEM FOR MODULATING AN IMMUNE RESPONSE |
摘要 |
The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower preference of usage by the mammal to confer the immune response than the codon it replaces.
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申请公布号 |
US2011287039(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US201113090932 |
申请日期 |
2011.04.20 |
申请人 |
FRAZER IAN HECTOR;DUTTON JULIE LOUISE;THE UNIVERSITY OF QUEENSLAND |
发明人 |
FRAZER IAN HECTOR;DUTTON JULIE LOUISE |
分类号 |
A61K39/00;A61P31/00;A61P33/00;C07H21/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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