The present invention provides methods of detecting activating mutations in exon 4 of a GNAQ or a GNA11 gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating such melanocytic neoplasm by modulating the activity of the mutated GNAQ or GNA11.
申请公布号
WO2011130691(A2)
申请公布日期
2011.10.20
申请号
WO2011US32765
申请日期
2011.04.15
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;THE UNIVERSITY OF BRITISH COLUMBIA;GRIEWANK, KLAUS G.;BASTIAN, BORIS C.;VAN RAAMSDONK, CATHERINE D.
发明人
GRIEWANK, KLAUS G.;BASTIAN, BORIS C.;VAN RAAMSDONK, CATHERINE D.
