The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of the peptide boronic acid proteasome inhibitor bortezomib.
申请公布号
EP2377868(A1)
申请公布日期
2011.10.19
申请号
EP20110167263
申请日期
2005.03.24
申请人
MILLENNIUM PHARMACEUTICALS, INC.
发明人
PICKERSGILL, I., FRASER;BISHOP, JOHN;LO, YOUNG;CHIU, FANG-TING;KULKARNI, VITHALANAND R.
