A genetically modified dermal micro-organ expressing erythropoietin and/or interferon

摘要

The present invention is directed to a genetically modified dermal micro-organ expressing at least one recombinant gene product, wherein said dermal micro-organ consists essentially of a plurality of dermal components and does not include epidermal layers, which maintains the micro-architecture and three dimensional structure of the dermal tissue from which it is derived, having dimensions selected so as to enable passive diffusion of adequate nutrients and gases to cells of said dermal micro-organ and diffusion of cellular waste out of said cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in said dermal micro organ, wherein at least some of said cells of said genetically modified dermal micro-organ express at least a portion of at least one recombinant gene product, wherein said recombinant gene product is erythropoietin.