The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
申请公布号
CA2552107(C)
申请公布日期
2011.10.18
申请号
CA20042552107
申请日期
2004.12.23
申请人
BRISTOL-MYERS SQUIBB COMPANY
发明人
FINK, BRIAN E.;GAVAI, ASHVINIKUMAR V.;VITE, GREGORY D.;CHEN, PING;MASTALERZ, HAROLD;NORRIS, DEREK J.;TOKARSKI, JOHN S.;ZHAO, YUFEN;HAN, WEN-CHING