| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: declared invention refers to chemical-pharmaceutical industry, and concerns a method for preparing a solid oral dosage form which contains a poorly soluble and/or poorly mouldable drug substance and a hydrophylic polymer. The method is implemented by using an extruder with an added unstable plasticiser in the form of a liquefied gas or a supercritical fluid, e.g. such as a supercritical carbon dioxide. The unstable plasticiser is added to accelerate material processing. ^ EFFECT: unstable plasticiser is used to reduce viscosity of the mould mixture, and/or improved solubility of the drug substance. ^ 9 cl, 2 ex |
