发明名称 |
METHOD AND COMPOSITIONS TO INDUCE APOPTOSIS OF TUMORAL CELLS EXPRESSING SHH |
摘要 |
The invention is relative to the use of an effective amount of an agonist of the CDO's apoptotic function for the preparation of a drug to induce cell apoptosis in a patient having tumoral cells bearing CDO and expressing SHH. The agonist may be a CDO fragment, a fusion protein comprising a CDO fragment, an antibody against SHH, or a siRNA which is capable of inhibiting SHH expression. The invention also concerns a pharmaceutical composition containing an agonist of the CDO's apoptotic function or a CDO polypeptide or an antibody specific to CDO, and an agonist of the PTC1's apoptotic function or a PTC1 polypeptide or an antibody specific to PTC1, and a pharmaceutically acceptable excipient or vehicle.
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申请公布号 |
CA2793750(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
CA20112793750 |
申请日期 |
2011.03.23 |
申请人 |
NETRIS PHARMA |
发明人 |
MEHLEN, PATRICK;DELLOYE-BOURGEOIS, CELINE;BERNET, AGNES;DELCROS, JEAN GUY;NONY, PASCALE |
分类号 |
A61K38/17;A61K39/395;A61P35/00;C12N15/11 |
主分类号 |
A61K38/17 |
代理机构 |
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地址 |
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