| 发明名称 |
COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS |
| 摘要 |
<p>The present invention is directed to methods and compositions for systemic delivery of minimally- soluble bioactive agents such as, but not limited to, proteins of the TGF-βsuperfamily. According to the invention, an exemplary bioactive agent is BMP-7 The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the site of intravascular delivery of the bioactive agent.</p> |
| 申请公布号 |
SG173634(A1) |
申请公布日期 |
2011.09.29 |
| 申请号 |
SG20110057684 |
申请日期 |
2010.02.12 |
| 申请人 |
STRYKER CORPORATION |
发明人 |
PECQUET GOAD, MARY, ELIZABETH;SCHRIER, DENIS;PIERCE, ALLEN, RICHARD |
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