HCV VARIANT WITH HIGH PRODUCTIVITY OF INFECTIOUS HEPATITIS C VIRUS, AND USE THEREOF

摘要

Provided is an HCV strain that exhibits high virus productivity in a cell culture system. The disclosed nucleic acid encodes a precursor polyprotein of hepatitis C virus JFH1 strain including at least one amino acid substitution. In the precursor polyprotein, at least the glutamine at position 862 according to the amino acid sequence represented by SEQ ID NO: 2 in the sequence listing is substituted by arginine.