| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of medicine, namely to chemical-pharmaceutical industry, in particular to drug form, such as capsule, ordinary or orally disintegrating tablet, able to deliver nitrogen-(N)-containing therapeutic medications, which have pKa in range from approximately 5 to 14 in organism in form with delayed release in order to be suitable for two-time or one-time day regimen of dosage, includes, at least, one organic acid, which solubilises medication before its release into unfavourable intestine environment, in which said medication is practically insoluble. ^ EFFECT: single drug form, composed of multitude of multi-layered particles, is manufactured in such a way, that said weak-base medication and said organic acid do not come into close contact with formation in situ of acidic adducts, guaranteeing that acid will not run out before release of medication finishes. ^ 39 cl, 1 tbl, 10 ex, 9 dwg |
