| 摘要 |
The present invention relates to polymeric antitumor agents in which polymeric complex micelle structures are formed by intermolecular binding or mutual interaction between styrene maleic acid copolymer (SMA) and a low molecular antitumor agent which is an anthracyclin drug such as pirarubicin, doxorubicin, epirbicin, daunorbicin, aclarubicin, or alkaloid antitumor agent such as cis-platinum or taxol. These polymeric micelle antitumor agents may improve selective accumulation of drugs to cancer tissue for improved antitumor effect, while concentrating less at normal organs or tissues, so that a lesser adverse effect may be accomplished. These polymeric antitumor agents may be prepared by dissolving SMA and a low molecular antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complexes, and separating and recovering the polymeric micelle component.
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