Process for the purification of meloxicam

摘要

A process for purifying meloxicam form I from a crude meloxicam, which comprises: i. contacting the crude meloxicam with an amine in a non-aqueous solvent to form a meloxicam salt; ii. isolating the meloxicam salt; iii. dissolving the meloxicam salt in an aqueous solvent to form a salt solution; and iv. adding an acid to the salt solution to precipitate free meloxicam.