A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF THROMBOSIS-RELATED DISEASES COMPRISING A FRAGMENT OF PROLACTIN (PRL)-GROWTH HORMONE (GH)-PLACENTAL LACTOGEN (PL)-FAMILY PROTEIN

摘要

The present invention refers to a pharmaceutical composition for use in the preventive and/or therapeutic treatment of thrombosis-related diseases or conditions relating to high level of PAI-1 expression, which composition is comprising A) a fragment of a polypeptide or protein of prolactin (PRL)-growth hormone (GH) - placental lactogen (PL)-family and homologous derivatives thereof, which fragment comprises from 6 to 14 consecutive amino acid residues of the amino acid sequence having the following general formula (I): X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11 -X12-X13-X14 (SEQ ID NO: 11), wherein X1 is an amino acid residue of : Leu, Phe; X2 is an amino acid residue of : Leu; X3 is an amino acid residue of : Arg, Ser; X4 is an amino acid residue of : Ile, Leu; X5 is an amino acid residue of : Ser, Ile; X6 is an amino acid residue of : Leu, VaI; X7 is an amino acid residue of : Leu, Ser, X8 is an amino acid residue of : Leu, lIe X9 is an amino acid residue of : Ile, Leu; X10 is an amino acid residue of : GIn, GIu, Arg; II 1 is an amino acid residue of : Ser; X12 is an amino acid residue of : Trp; X13 is an amino acid residue of : Leu, Asn; X14 is an amino acid residue of : GIu; or B) a peptide or a recombinant protein comprising said peptide, wherein the peptide is from 6 to 50 amino acids in length and has the activity to inhibit plasminogen activator inhibitor I (PAI-1 ), said peptide comprising from 6 to 14 consecutive amino acid residues of the amino acid sequence of said general formula (I); or C) a polynucleotide encoding said fragment of a polypeptide or protein of A) or said peptide or recombinant protein of B).