A NOVEL WATER SOLUBLE CURCUMIN LOADED NANOPARTICULATE SYSTEM FOR CANCER THERAPY

摘要

The present invention provides a drug delivery system encompassing a water-insoluble drug curcumin for the treatment of cancer. The composition is containing a pharmaceutically acceptable carrier and thus providing a biocompatible drug delivery system. The invention further discloses the nanoparticles composed of glycerol monooleate (GMO), polyvinyl alcohol and pluronic F- 127 and it showed high surface charge (around -32 mV) demonstrating enhanced solubility, stability and bioavailability of entrapped curcumin.