| 发明名称 |
Treatment of Non-Neuronal Cancer using HSV-1 Variants |
| 摘要 |
A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma, bladder cancer or melanoma. Typically, the mutant herpes simplex virus has been modified within the BamHI restriction fragment of the long terminal repeat of the viral genome.
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| 申请公布号 |
US2011195053(A1) |
申请公布日期 |
2011.08.11 |
| 申请号 |
US201113090983 |
申请日期 |
2011.04.20 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;CRUSADE LABORATORIES LIMITED;WISTAR INSTITUTE |
发明人 |
BROWN SUSANNE M.;MACLEAN ALASDAIR R.;FRASER NIGEL W.;RANDAZZO BRUCE P.;ALBELDA STEVEN;KAISER LARRY;KUCHARCZUK JOHN |
| 分类号 |
A61K35/76;A61P35/00;A61P35/04 |
主分类号 |
A61K35/76 |
| 代理机构 |
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代理人 |
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