| 摘要 |
Disclosed are: an induced hepatic stem cell useful for safety tests, toxicity tests, metabolism tests, drug interaction tests, anti-viral activity tests, screening tests for medicinal agents such as hyperlipemia therapeutic agents, hypertension therapeutic agents, pharmaceutical low-molecular-weight compound agents and pharmaceutical antibody agents, the screening for potential drug targets, the production of animal models, the production of hepatocyte-produced proteins, and regenerative medicine; a process for producing the cell; and applications of the cell. The induced hepatic stem cell is characterized by fulfilling at least the following requirements (1) to (3): (1) at least 15 genes selected from specific genes that are marker genes for embryonic stem cells are expressed in the cell; (2) the cell has properties of hepatocytes; and (3) the cell can be proliferatively cultured or sub-cultured for at least three days.
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