METHODS OF INHIBITING RETROVIRUS REPLICATION AND INFECTIVITY

摘要

Methods of inhibiting replication or reducing infectivity of a retrovirus by administering a therapeutically effective amount of MOV10 polypeptide, or a fragment, derivative or analog thereof or an inhibitor of MOV10 or a fragment, derivative or analog thereof are disclosed. Further disclosed are methods of increasing or decreasing transcription, translation or biological activity of MOV10 or a fragment, derivative or analog thereof. Also disclosed are methods to identify an agent that may inhibit a retrovirus comprising identifying an agent that is regulated by MOV10 or a fragment, derivative or analog thereof.