CONTROLLED-RELEASE COMPOSITION

摘要

PROBLEM TO BE SOLVED: To provide a solid dosage formulation for providing controlled-release of a pharmacological agent. SOLUTION: There is provided a solid dosage formulation having: a core tablet with a pharmacological agent dispersed in a first controlled-release matrix from which release of the agent is relatively slow; and a coating formed and covering the core tablet and containing tramadol dispersed in a second controlled-release matrix from which release of the tramadol is relatively fast. COPYRIGHT: (C)2011,JPO&INPIT