发明名称 |
POLYMER CONJUGATES OF OPIOID ANTAGONISTS |
摘要 |
This invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugates of the invention. |
申请公布号 |
CA2463938(C) |
申请公布日期 |
2011.08.09 |
申请号 |
CA20022463938 |
申请日期 |
2002.10.18 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
BENTLEY, MICHAEL DAVID;ROBERTS, MICHAEL JAMES;SHEN, XIAOMING;CHENG, LIN |
分类号 |
A61K47/30;A61K47/48;A61K31/485;A61K45/00;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61P1/08;A61P1/10;A61P17/04;A61P25/02 |
主分类号 |
A61K47/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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