A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I: X-W wherein X is a caspase-selective structure and W has the structure of -NH-CH(Y)(Z) wherein Y is a structure that can form a reversible covalent bond with a caspase; and Z is selected from a carboxyl moiety or a carboxylic acid mimetic.
申请公布号
WO2011094426(A1)
申请公布日期
2011.08.04
申请号
WO2011US22744
申请日期
2011.01.27
申请人
THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES;THOMAS, CRAIG;BOXER, MATTHEW, B.
