发明名称 |
CARTRIDGE GENETIC MAKER EXPRESSING THREE BIOLOGICALLY ACTIVE siPHK, EFFECTIVELY ATTACKING HUMAN IMMUNODEFICIENCY VIRUS AND CCR5 GENE TRANSCRIPTS BY MEANS OF RNA-INTERFERENCE |
摘要 |
FIELD: medicine. ^ SUBSTANCE: what is described in a cartridge genetic maker based on GeneClip-Ul-neo vector producing three siRNA - reproduction inhibitors of human immunodeficiency virus type 1 and human CCR5 gene. The maker contains a fragment of the length 27 bp related to a conservative region of a HIV-1 genome reverse transcriptase domain, a fragment of the length 27 bp related to the other conservative region of the HIV-1 genome reverse transcriptase domain, as well as a fragment 19 bp related to CCR5 gene mRNA. The invention can be used in medicine and scientific research. ^ EFFECT: invention allows producing more effective anti-HIV preparations based on interfering RNA produced in cells by means of the introduced cartridge genetic maker containing palindromes for three siRNA production. ^ 3 dwg, 2 tbl, 2 ex |
申请公布号 |
RU2425150(C1) |
申请公布日期 |
2011.07.27 |
申请号 |
RU20090142859 |
申请日期 |
2009.11.23 |
申请人 |
UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT MOLEKULJARNOJ BIOLOGII IM. V.A. EHNGEL'GARDTA RAN;ROSSIJSKAJA FEDERATSIJA, OT IMENI KOTOROJ VYSTUPAET MINISTERSTVO OBRAZOVANIJA I NAUKI ROSSIJSKOJ FEDERATSII |
发明人 |
CHURIKOV NIKOLAJ ANDREEVICH;KRETOVA OL'GA VALER'EVNA |
分类号 |
A61K39/21;C12N15/63 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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地址 |
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