NOVEL CRYSTAL FORMS OF 4-(2-AMINOPYRIDIN-4-YL)-3-(4-FLUOROPHENYL)-1-(1,4,5,6-TETRAHYDRO-6-OXOPYRIDAZIN-3-YL)-1H-PYRAZOLE METHANESULFONATE AND METHODS FOR THEIR PREPARATION

摘要

The present inventions are directed to novel crystal forms of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-(1,4,5,6-tetrahydro-6-oxopyridazin-3-yl)-1H-pyrazole methanesulfonate, which is useful as a pharmaceutical product, and methods for their preparation. The present inventions provide two stable crystalline polymorphs called A-form crystal and B-form crystal as well as methods for their preparation, by which each crystalline polymorph can be individually obtained as a single crystal form.