发明名称 |
COMPOSITION AND METHOD FOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS |
摘要 |
Described are methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a cell or population of cells characteristic of the definitive endoderm, the method comprising incubating the cell or population of cells with a GSK-3 inhibitor. Also described are methods for inducing differentiation of a cell or population of cells, characteristic of the definitive endoderm, towards a hepatocyte-like cell or a population of hepatocyte-like cells, and methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a hepatocyte-like cell or a population of hepatocyte-like cells. Further described are cells obtained by the methods and uses thereof in therapy and toxicity screening. |
申请公布号 |
WO2011064549(A2) |
申请公布日期 |
2011.06.03 |
申请号 |
WO2010GB02184 |
申请日期 |
2010.11.26 |
申请人 |
STEM CELLS FOR SAFER MEDICINES LIMITED;BONE, HEATHER KARYN;TOSH, DAVID;WELHAM, MELANIE JOANNE |
发明人 |
BONE, HEATHER KARYN;TOSH, DAVID;WELHAM, MELANIE JOANNE |
分类号 |
C12N5/0735 |
主分类号 |
C12N5/0735 |
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