METHOD FOR MANUFACTURING A 6-SUBSTITUTED-1-METHYL-1H-BENZIMIDAZOLE DERIVATIVE AND AN INTERMEDIATE OF SAID METHOD

摘要

Provided is a novel method for manufacturing a 6-substituted-1-methyl-1H-benzimidazole derivative. Also provided is a manufacturing intermediate from said method. The provided method, which manufactures a 6-substituted-1-methyl-1H-benzimidazole derivative represented by general formula (IV) (in which R3 represents a hydrogen atom or a C1-4 alkyl group), is characterized by: manufacturing a 4-substituted-N2-methylbenzene-1,2-diamine derivative from a specific 5-substituted-N-methyl-2-nitroaniline derivative; reacting same with {4-[(2,4-dioxo-1,3-thiazolidine-5-yl)methyl]phenoxy} acetate or an oxychloride or mixed acid anhydride thereof; and then performing intramolecular dehydration/condensation.