MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION

摘要

THE PRESENT INVENTION CONCERNS MORPHOLINYL CONTAINING BENZIMIDAZOLES HAVING INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS AND HAVING THE FORMULA A PRODRUG, N-OXIDE, ADDITION SALT, QUATERNARY AMINE, METAL COMPLEX OR STEREOCHEMICALLY ISOMERIC FORM THEREOF WHEREIN G IS A DIRECT BOND OR OPTIONALLY SUBSTITUTED C1-10ALKANEDIYL; R1 IS AR1 OR A MONOCYCLIC OR BICYCLIC HETEROCYCLE Q IS R7, PYRROLIDINYL SUBSTITUTED WITH R7, PIPERIDINYL SUBSTITUTED WITH R7 OR HOMOPIPERIDINYL SUBSTITUTED WITH R7; ONE OF R2A AND R3A IS SELECTED FROM HALO, OPTIONALLY MONO- OR POLYSUBSTITUTED C1-6ALKYL, OPTIONALLY MONO- OR POLYSUBSTITUTED C2-6ALKENYL, NITRO, HYDROXYL, AR2, N(R4AR4B), N(R4AR4B)SULFONYL, N(R4AR4B)CARBONYL, C1-6ALKYLOXY, AR2 OXY, AR2C1-6ALKYLOXY, CARBOXYL, C1-6ALKYLOXYCARBONYL, OR–C(=Z)AR2; AND THE OTHER ONE OF R2A AND R3A IS HYDROGEN; IN CASE R2A IS DIFFERENT FROM HYDROGEN THEN R2B IS HYDROGEN, C1-6ALKYL OR HALOGEN AND R3B IS HYDROGEN; IN CASE R3A IS DIFFERENT FROM HYDROGEN THEN R3B IS HYDROGEN, C1-6ALKYL OR HALOGEN AND R2B IS HYDROGEN. IT FURTHER CONCERNS THE PREPARATION THEREOF AND COMPOSITIOS COMPRISING THESE COMPOUNDS, AS WELL AS THE USE THEREOF AS A MEDICINE.